Article
Noncovalent association with stress protein facilitates cross-priming of CD8+ T cells to tumor cell antigens by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2002
Kammerer Robert, Stober Detlef, Riedl Petra, Oehninger Claude, Schirmbeck Reinhold, Reimann Jörg
Abstract excerpt
A viral oncogene carrying well-defined K(b)/D(b)-restricted epitopes was expressed in a heat shock protein (hsp)-associated or nonassociated form in the murine tumor cells P815 and Meth-A. Wild-type SV40 large T-Ag (wtT-Ag) is expressed without stable hsp association; mutant (cytoplasmic cT-Ag) or chimeric (cT272-green fluorescent fusion protein) T-Ag is expressed in stable association with the constitutively...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
