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Article

The impact of misfolding versus targeted degradation on the efficiency of the MHC class I-restricted antigen processing.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2005

Golovina Tatiana N, Morrison Susan E, Eisenlohr Laurence C

Abstract excerpt

Evidence suggests that most epitopes presented by MHC class I molecules are derived from those newly synthesized proteins that are defective due to errors during manufacture. We examined epitope production from model cytosolic and exocytic proteins modified in various ways. Substrates containing a degradation targeting sequence demonstrated very rapid turnover and enhanced epitope production, as was the case for...

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Source

Identifiers

PMID: 15728485
DOI: 10.4049/jimmunol.174.5.2763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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