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Article

Biallelic expression of the H19 and IGF2 genes in human testicular germ cell tumors.

Journal of the National Cancer Institute - 20 Jul 1994

van Gurp R J, Oosterhuis J W, Kalscheuer V, Mariman E C, Looijenga L H

Abstract excerpt

BACKGROUND: Genomic imprinting, resulting in the nonequivalence of expression of homologue genes depending on their parental origin, is an important determinant of the developmental potential of embryonic cells. The expression of two genes, one termed H19 and the other IGF2, has been found to be necessary for proper embryonal development in humans. Both the murine and human H19 and IGF2 genes are normally...

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Source

Identifiers

PMID: 8021956
DOI: 10.1093/jnci/86.14.1070

Genes

IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biallelic expression of the H19 and IGF2 genes in human testicular germ cell tumors.PMID 8021956Read ↗

Genomic imprinting of H19 and insulin-like growth factor-2 in pediatric germ cell tumorsSemantic proximity Read ↗

Equivalent parental distribution of frequently lost alleles and biallelic expression of the H19 gene in human testicular germ cell tumors.Semantic proximity Read ↗

Imprinted H19 gene expression in embryogenesis and human cancer: the oncofetal connection.Semantic proximity Read ↗

Frequent loss of imprinting of the H19 and IGF-II genes in ovarian tumors.Semantic proximity Read ↗

Relaxation of imprinted genes in human cancer.Semantic proximity Read ↗

Random monoallelic expression of the imprinted IGF2 and H19 genes in the absence of discriminative parental marks.Semantic proximity Read ↗

High incidence of loss of heterozygosity and abnormal imprinting of H19 and IGF2 genes in invasive cervical carcinomas. Uncoupling of H19 and IGF2 expression and biallelic hypomethylation of H19.Semantic proximity Read ↗

Igf2-H19, an imprinted tandem gene, is an important regulator of embryonic development, a guardian of proliferation of adult pluripotent stem cells, a regulator of longevity, and a ‘passkey’ to cancerogenesisSemantic proximity Read ↗

Genomic imprinting and Wilms' tumor.Semantic proximity Read ↗

Imprinting and expression of insulin-like growth factor-II and H19 in normal breast tissue and breast tumor.Semantic proximity Read ↗

Symmetric and asymmetric DNA methylation in the human IGF2-H19 imprinted region.Semantic proximity Read ↗

Loss of imprinting of igf2 in renal-cell carcinomas.Semantic proximity Read ↗

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