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Article

Imprinting and expression of insulin-like growth factor-II and H19 in normal breast tissue and breast tumor.

The Journal of clinical endocrinology and metabolism - 1 Apr 1996

Yballe C M, Vu T H, Hoffman A R

Abstract excerpt

Insulin-like growth factor (IGF)-II is a mitogenic peptide that has been reported to play an important role in the formation and growth of a variety of tumors. In most tissues, the IGF-II gene (IGF2) is parentally imprinted, with only the paternal allele being expressed. IGF2 messenger RNA (mRNA) and protein are overexpressed in some benign and malignant tumors. H19, a tumor suppressor gene located directly...

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Identifiers

PMID: 8636375
DOI: 10.1210/jcem.81.4.8636375

Genes

IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Imprinting and expression of insulin-like growth factor-II and H19 in normal breast tissue and breast tumor.PMID 8636375Read ↗

Frequent loss of imprinting of the H19 and IGF-II genes in ovarian tumors.Semantic proximity Read ↗

Igf2-H19, an imprinted tandem gene, is an important regulator of embryonic development, a guardian of proliferation of adult pluripotent stem cells, a regulator of longevity, and a ‘passkey’ to cancerogenesisSemantic proximity Read ↗

Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern.Semantic proximity Read ↗

Loss of imprinting of igf2 in renal-cell carcinomas.Semantic proximity Read ↗

Genomic imprinting of IGF-II and H19 in adult human pancreatic tissues.Semantic proximity Read ↗

Alterations in promoter usage and expression levels of insulin-like growth factor-II and H19 genes in cervical carcinoma exhibiting biallelic expression of IGF-II.Semantic proximity Read ↗

The product of the imprinted H19 gene is an oncofetal RNA.Semantic proximity Read ↗

Genomic imprinting of H19 and insulin-like growth factor-2 in pediatric germ cell tumorsSemantic proximity Read ↗

Frequent loss of imprinting at the IGF2 and H19 genes in head and neck squamous carcinomaSemantic proximity Read ↗

IGF2: epigenetic regulation and role in development and disease.Semantic proximity Read ↗

The insulin-like growth factor type-2 receptor gene is imprinted in the mouse but not in humans.Semantic proximity Read ↗

Dissociation of IGF2 and H19 imprinting in human brain.Semantic proximity Read ↗

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