Imprinting and expression of insulin-like growth factor-II and H19 in normal breast tissue and breast tumor.

doi:10.1210/jcem.81.4.8636375

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Article

Imprinting and expression of insulin-like growth factor-II and H19 in normal breast tissue and breast tumor.

The Journal of clinical endocrinology and metabolism - 1 Apr 1996

Yballe C M, Vu T H, Hoffman A R

Abstract excerpt

Insulin-like growth factor (IGF)-II is a mitogenic peptide that has been reported to play an important role in the formation and growth of a variety of tumors. In most tissues, the IGF-II gene (IGF2) is parentally imprinted, with only the paternal allele being expressed. IGF2 messenger RNA (mRNA)...

Topics

Alleles
Base Sequence
Breast
Breast Neoplasms
DNA Primers
DNA, Complementary
Deoxyribonucleases, Type II Site-Specific
Exons
Female
Gene Expression
Genes, Tumor Suppressor
Genomic Imprinting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Insulin-Like Growth Factor II

Male

Molecular Sequence Data

Muscle Proteins

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 8636375
DOI: 10.1210/jcem.81.4.8636375

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8636375-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Imprinting and expression of insulin-like growth factor-II and H19 in normal breast tissue and breast tumor.PMID 8636375Read ↗

Frequent loss of imprinting of the H19 and IGF-II genes in ovarian tumors.Semantic proximity Read ↗

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