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Article

Genomic imprinting and Wilms' tumor.

Medical and pediatric oncology - 1 Nov 1996

Moulton T, Chung W Y, Yuan L, Hensle T, Waber P, Nisen P, Tycko B

Abstract excerpt

The selective loss of maternal and reduplication of paternal chromosome 11p15.5 alleles in Wilms' tumors (WTs) points to the existence of a paternally imprinted tumor suppressor gene(s) and/or a maternally imprinted dose-dependent growth-promoting gene(s) in this chromosomal region. Two reciprocally imprinted chromosome 11p15.5 genes, H19, a candidate tumor suppressor gene, and IGF2, a candidate dominant...

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Source

Identifiers

PMID: 8827077
DOI: 10.1002/(SICI)1096-911X(199611)27:5<476::AID-MPO15>3.0.CO;2-8

Genes

IGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Genomic imprinting and Wilms' tumor.PMID 8827077Read ↗

Chromosome 11p15.5 regional imprinting: comparative analysis of KIP2 and H19 in human tissues and Wilms' tumors.Semantic proximity Read ↗

Role of genomic imprinting in Wilms' tumour and overgrowth disorders.Semantic proximity Read ↗

Relaxation of imprinted genes in human cancer.Semantic proximity Read ↗

Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour.Semantic proximity Read ↗

Epigenetic changes encompassing the IGF2/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor.Semantic proximity Read ↗

Genomic imprinting and carcinogenesis.Semantic proximity Read ↗

Epigenetic lesions at the H19 locus in Wilms' tumour patients.Semantic proximity Read ↗

Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumourSemantic proximity Read ↗

Paternally Inherited Submicroscopic Duplication at 11p15.5 Implicates Insulin-like Growth Factor II in Overgrowth and Wilms' TumorigenesisSemantic proximity Read ↗

Imprinting mutation in the Beckwith-Wiedemann syndrome leads to biallelic IGF2 expression through an H19-independent pathway.Semantic proximity Read ↗

Beckwith-Wiedemann syndrome demonstrates a role for epigenetic control of normal development.Semantic proximity Read ↗

Genomic profiling maps loss of heterozygosity and defines the timing and stage dependence of epigenetic and genetic events in Wilms' tumors.Semantic proximity Read ↗

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