Article
Random monoallelic expression of the imprinted IGF2 and H19 genes in the absence of discriminative parental marks.
Development genes and evolution - 1 Feb 1999
Ohlsson R, Flam F, Fisher R, Miller S, Cui H, Pfeifer S, Adam G I
Abstract excerpt
The IGF2 and H19 genes are genomically imprinted and expressed preferentially from the paternal and maternal alleles, respectively, during human prenatal development. The exact role of the parental imprint(s), however, is not known. To explore this issue in some detail, we have examined human androgenetic cells which by definition should be incapable of allelic discrimination given the paternal origin of both...
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