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Article

Equivalent parental distribution of frequently lost alleles and biallelic expression of the H19 gene in human testicular germ cell tumors.

Japanese journal of cancer research : Gann - 1 Aug 1996

Mishina M, Ogawa O, Kinoshita H, Oka H, Okumura K, Mitsumori K, Kakehi Y, Reeve A E, Yoshida O

Abstract excerpt

Epigenetic alterations such as genomic imprinting might play an important role in human tumorigenesis, in addition to specific genetic alterations. To clarify the role of genetic and/or epigenetic alterations in the tumorigenesis of testicular germ cell tumors (GCTs), we analyzed 40 primary and 3 metastatic testicular GCTs with regard to specific chromosomal losses and their parental origin. A high incidence of...

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Identifiers

PMID: 8797887
DOI: 10.1111/j.1349-7006.1996.tb02105.x
PMCID: PMC5921178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Equivalent parental distribution of frequently lost alleles and biallelic expression of the H19 gene in human testicular germ cell tumors.PMID 8797887Read ↗

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Preferential loss of paternal 19q, but not 1p, alleles in oligodendrogliomas.Semantic proximity Read ↗

Methylation similarities of two CpG sites within exon 5 of human H19 between normal tissues and testicular germ cell tumours of adolescents and adults, without correlation with allelic and total level of expression.Semantic proximity Read ↗

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The H19 methylation imprint is erased and re-established differentially on the parental alleles during male germ cell development.Semantic proximity Read ↗

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