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Article

Genomic imprinting of H19 and insulin-like growth factor-2 in pediatric germ cell tumors

15 Mar 1999

Abstract excerpt

BACKGROUND: Insulin-like growth factor-2 (IGF2) and H19 are reciprocally imprinted genes on chromosome 11; IGF2 is expressed paternally and H19 is expressed maternally. Loss of imprinting (LOI) at both H19 and IGF2 has been reported in seven fully informative adult testicular germ cell tumors (GCTs) and may contribute to germ cell carcinogenesis. METHODS: Genomic DNA from 61 pediatric GCTs was amplified by...

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PMID: 10189147
DOI: 10.1002/(sici)1097-0142(19990315)85:6<1389::aid-cncr24>3.0.co;2-v

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Genomic imprinting of H19 and insulin-like growth factor-2 in pediatric germ cell tumorsPMID 10189147Read ↗

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