14-3-3 epsilon positively regulates Ras-mediated signaling in Drosophila.

doi:10.1101/gad.11.9.1132

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Article

14-3-3 epsilon positively regulates Ras-mediated signaling in Drosophila.

Genes & development - 1 May 1997

Chang H C, Rubin G M

Abstract excerpt

We have isolated mutations in the gene encoding a Drosophila 14-3-3 epsilon protein as suppressors of the rough eye phenotype caused by the ectopic expression of RAS1(V12). Using a simple loss-of-function 14-3-3 epsilon mutation, we show that 14-3-3 epsilon acts to increase the efficiency of RAS1...

Topics

14-3-3 Proteins
Alleles
Amino Acid Sequence
Animals
Drosophila
Eye
Genes, Insect
Microscopy, Electron, Scanning
Models, Molecular
Molecular Sequence Data
Mutation
Phenotype
Protein Serine-Threonine Kinases
Proteins
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-raf
Sequence Homology, Amino Acid
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 9159394
DOI: 10.1101/gad.11.9.1132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9159394-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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