Article
A temperature-sensitive MEK mutation demonstrates the conservation of the signaling pathways activated by receptor tyrosine kinases.
Genes & development - 15 Sept 1994
Hsu J C, Perrimon N
Abstract excerpt
MEK, a dual specificity threonine/tyrosine kinase, has been postulated to be a convergent point for signaling from receptor protein tyrosine kinases (RTKs) and G-protein-coupled receptors. In contrast to yeast and mammalian cells where several MEKs have been isolated, only one Drosophila MEK (D-M...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Conserved Sequence
- DNA Primers
- Drosophila
- Female
- Gene Expression Regulation, Developmental
- Gene Expression Regulation, Enzymologic
- Genes, Insect
- MAP Kinase Kinase 1
- Male
- Mitogen-Activated Protein Kinase Kinases
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Protein Serine-Threonine Kinases