Article
Dominant mutations of Drosophila MAP kinase kinase and their activities in Drosophila and yeast MAP kinase cascades.
Genetics - 1 May 1997
Lim Y M, Tsuda L, Inoue Y H, Irie K, Adachi-Yamada T, Hata M, Nishi Y, Matsumoto K, Nishida Y
Abstract excerpt
Eight alleles of Dsor1 encoding a Drosophila homologue of mitogen-activated protein (MAP) kinase kinase were obtained as dominant suppressors of the MAP kinase kinase kinase D raf. These Dsor1 alleles themselves showed no obvious phenotypic consequences nor any effect on the viability of the flies, although they were highly sensitive to upstream signals and strongly interacted with gain-of-function mutations of...
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