Article
Interethnic differences in omeprazole metabolism in the two S-mephenytoin hydroxylation phenotypes studied in Caucasians and Orientals.
Therapeutic drug monitoring - 1 Apr 1994
Ishizaki T, Sohn D R, Kobayashi K, Chiba K, Lee K H, Shin S G, Andersson T, Regårdh C G, Lou Y C, Zhang Y
Abstract excerpt
Two independent studies showed that the 5-hydroxylation, but not the sulfoxidation, of omeprazole is more rapid in extensive metabolizers (EMs) than in poor metabolizers (PMs) of S-mephenytoin. In Caucasian, Chinese, and Korean PMs, the mean oral clearances were similar and not significantly diff...
Topics
- Aryl Hydrocarbon Hydroxylases
- Asian People
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 Enzyme System
- Humans
- Mixed Function Oxygenases
- Omeprazole
- Phenotype
- White People