Article
Interethnic differences in omeprazole metabolism in the two S-mephenytoin hydroxylation phenotypes studied in Caucasians and Orientals.
Therapeutic drug monitoring - 1 Apr 1994
Ishizaki T, Sohn D R, Kobayashi K, Chiba K, Lee K H, Shin S G, Andersson T, Regårdh C G, Lou Y C, Zhang Y
Abstract excerpt
Two independent studies showed that the 5-hydroxylation, but not the sulfoxidation, of omeprazole is more rapid in extensive metabolizers (EMs) than in poor metabolizers (PMs) of S-mephenytoin. In Caucasian, Chinese, and Korean PMs, the mean oral clearances were similar and not significantly different (85, 73, and 59 ml h-1 kg-1, respectively). However, the geometric mean clearance in Caucasian EMs (950 ml h-1...
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