Article
Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19.
Clinical pharmacokinetics - 1 Sept 1995
Bertilsson L
Abstract excerpt
The isoenzymes which catalyse the polymorphic hydroxylations of debrisoquine/sparteine and S-mephenytoin are cytochromes P450 2D6 and P450 2C19 (CYP2D6 and CYP2C19), respectively. CYP2D6 is involved in the stereospecific metabolism of several important groups of drugs, for example antiarrhythmics...
Topics
- Antidepressive Agents
- Antipsychotic Agents
- Aryl Hydrocarbon Hydroxylases
- Asian People
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Diazepam
- Geography
- Humans
- Mixed Function Oxygenases
- Mutation
- Omeprazole
- Pharmaceutical Preparations
- Phenotype
- Polymorphism, Genetic
- Racial Groups
- Substrate Specificity