Article
Pharmacokinetics/genotype associations for major cytochrome P450 enzymes in native and first- and third-generation Japanese populations: comparison with Korean, Chinese, and Caucasian populations.
Clinical pharmacology and therapeutics - 1 Sept 2008
Myrand S P, Sekiguchi K, Man M Z, Lin X, Tzeng R-Y, Teng C-H, Hee B, Garrett M, Kikkawa H, Lin C-Y, Eddy S M, Dostalik J, Mount J, Azuma J, Fujio Y, Jang I-J, Shin S-G, Bleavins M R, Williams J A, Paulauskis J D, Wilner K D
Abstract excerpt
Application of foreign clinical data across geographic regions can accelerate drug development. Drug disposition can be variable, and identification of factors influencing responsible pharmacokinetic/pharmacogenomic approaches could facilitate the universal application of foreign data and reduce the total amount of phase III clinical trials evaluating risks in different populations. Our objective was to establish...
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