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Article

Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics.

Clinical pharmacology and therapeutics - 1 Aug 1992

Sohn D R, Kusaka M, Ishizaki T, Shin S G, Jang I J, Shin J G, Chiba K

Abstract excerpt

We studied the genetically determined hydroxylation polymorphism of S-mephenytoin in a Korean population (N = 206) and the pharmacokinetics of diazepam and demethyldiazepam after an oral 8 mg dose of diazepam administered to the nine extensive metabolizers and eight poor metabolizers recruited from the population. The log10 percentage of 4-hydroxymephenytoin excreted in the urine 8 hours after administration...

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Identifiers

PMID: 1505151
DOI: 10.1038/clpt.1992.125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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