Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics.

doi:10.1038/clpt.1992.125

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Article

Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics.

Clinical pharmacology and therapeutics - 1 Aug 1992

Sohn D R, Kusaka M, Ishizaki T, Shin S G, Jang I J, Shin J G, Chiba K

Abstract excerpt

We studied the genetically determined hydroxylation polymorphism of S-mephenytoin in a Korean population (N = 206) and the pharmacokinetics of diazepam and demethyldiazepam after an oral 8 mg dose of diazepam administered to the nine extensive metabolizers and eight poor metabolizers recruited fr...

Topics

Adult
Asian People
Creatinine
Diazepam
Female
Humans
Hydroxylation
Korea
Male
Mephenytoin
Mixed Function Oxygenases
Nordazepam
Phenotype
Polymorphism, Genetic

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