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Article

Metabolic disposition of imipramine in oriental subjects: relation to metoprolol alpha-hydroxylation and S-mephenytoin 4'-hydroxylation phenotypes.

The Journal of pharmacology and experimental therapeutics - 1 Nov 1994

Koyama E, Sohn D R, Shin S G, Chiba K, Shin J G, Kim Y H, Echizen H, Ishizaki T

Abstract excerpt

We studied the metabolic disposition of imipramine by measuring imipramine and its metabolites in plasma and urine simultaneously after a single oral dose of 25 mg of imipramine hydrochloride administered to 16 healthy (three Japanese and 13 Korean) volunteers. Four of the subjects were poor meta...

Topics

Adult
Asian People
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Dealkylation
Female
Humans
Hydroxylation
Imipramine
Isoenzymes
Male
Mephenytoin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Metoprolol

Mixed Function Oxygenases

Phenotype

Source

Identifiers

PMID: 7965806

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7965806-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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