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Article

Analysis of somatic mutation in five B cell subsets of human tonsil.

The Journal of experimental medicine - 1 Jul 1994

Pascual V, Liu Y J, Magalski A, de Bouteiller O, Banchereau J, Capra J D

Abstract excerpt

Using a series of phenotypic markers that include immunoglobulin (Ig)D, IgM, IgG, CD23, CD44, Bcl-2, CD38, CD10, CD77, and Ki67, human tonsillar B cells were separated into five fractions representing different stages of B cell differentiation that included sIgD+ (Bm1 and Bm2), germinal center (B...

Topics

Antigens, CD
B-Lymphocyte Subsets
Base Sequence
Genes, Immunoglobulin
Humans
Immunoglobulin D
Immunoglobulin G
Immunoglobulin Heavy Chains
Immunoglobulin M
Immunoglobulin Variable Region
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Palatine Tonsil

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 8006591
DOI: 10.1084/jem.180.1.329
PMCID: PMC2191579

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8006591-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Analysis of somatic mutation in five B cell subsets of human tonsil.PMID 8006591Read ↗

Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes.Semantic proximity Read ↗

Sequential triggering of apoptosis, somatic mutation and isotype switch during germinal center development.Semantic proximity Read ↗

Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutation.Semantic proximity Read ↗

Somatic hypermutation in normal and transformed human B cells.Semantic proximity Read ↗

Normal human IgD+IgM- germinal center B cells can express up to 80 mutations in the variable region of their IgD transcripts.Semantic proximity Read ↗

Amino acid insertions and deletions contribute to diversify the human Ig repertoire.Semantic proximity Read ↗

In vitro triggering of somatic mutation in human naive B cells.Semantic proximity Read ↗

Molecular analysis of IgD-positive human germinal centres.Semantic proximity Read ↗

CD5+ B cells with the features of subepithelial B cells found in human tonsils.Semantic proximity Read ↗

The majority of human tonsillar CD5+ B cells express somatically mutated V kappa 4 genes.Semantic proximity Read ↗

Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age.Semantic proximity Read ↗

Memory B lymphocytes in human tonsil do not express surface IgD.Semantic proximity Read ↗

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