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Article

Analysis of somatic mutation in five B cell subsets of human tonsil.

The Journal of experimental medicine - 1 Jul 1994

Pascual V, Liu Y J, Magalski A, de Bouteiller O, Banchereau J, Capra J D

Abstract excerpt

Using a series of phenotypic markers that include immunoglobulin (Ig)D, IgM, IgG, CD23, CD44, Bcl-2, CD38, CD10, CD77, and Ki67, human tonsillar B cells were separated into five fractions representing different stages of B cell differentiation that included sIgD+ (Bm1 and Bm2), germinal center (Bm3 and Bm4), and memory (Bm5) B cells. To establish whether the initiation of somatic mutation correlated with this...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 8006591
DOI: 10.1084/jem.180.1.329
PMCID: PMC2191579

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of somatic mutation in five B cell subsets of human tonsil.PMID 8006591Read ↗

Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes.Semantic proximity Read ↗

Sequential triggering of apoptosis, somatic mutation and isotype switch during germinal center development.Semantic proximity Read ↗

Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutation.Semantic proximity Read ↗

Somatic hypermutation in normal and transformed human B cells.Semantic proximity Read ↗

Normal human IgD+IgM- germinal center B cells can express up to 80 mutations in the variable region of their IgD transcripts.Semantic proximity Read ↗

Amino acid insertions and deletions contribute to diversify the human Ig repertoire.Semantic proximity Read ↗

In vitro triggering of somatic mutation in human naive B cells.Semantic proximity Read ↗

Molecular analysis of IgD-positive human germinal centres.Semantic proximity Read ↗

CD5+ B cells with the features of subepithelial B cells found in human tonsils.Semantic proximity Read ↗

The majority of human tonsillar CD5+ B cells express somatically mutated V kappa 4 genes.Semantic proximity Read ↗

Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age.Semantic proximity Read ↗

Memory B lymphocytes in human tonsil do not express surface IgD.Semantic proximity Read ↗

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