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Article

Somatic hypermutation in normal and transformed human B cells.

Immunological reviews - 1 Apr 1998

Klein U, Goossens T, Fischer M, Kanzler H, Braeuninger A, Rajewsky K, Küppers R

Abstract excerpt

In the human, most IgM+IgD+ as well as CD5+ peripheral blood B cells express unmutated V genes and thus can be assigned to a pre-germinal centre (GC) stage of development. The memory B-cell compartment generated in the GC reaction and characterized by cells bearing somatically mutated V-region ge...

Topics

Animals
Antibody Diversity
B-Lymphocytes
Cell Transformation, Neoplastic
Genes, Immunoglobulin
Humans
Immunoglobulin Variable Region
Lymphocyte Subsets
Lymphoma, B-Cell
Mutation
Point Mutation
Polymerase Chain Reaction

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Identifiers

PMID: 9602370
DOI: 10.1111/j.1600-065x.1998.tb01447.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9602370-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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