Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutation.

doi:10.1016/s1074-7613(00)80432-x

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Article

Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutation.

Immunity - 1 Mar 1996

Liu Y J, Malisan F, de Bouteiller O, Guret C, Lebecque S, Banchereau J, Mills F C, Max E E, Martinez-Valdez H

Abstract excerpt

Human tonsillar B cells were separated into naive IgD+CD38-CD23- (Bm1) and IgD+CD38-CD23 (Bm2), germinal center IgD-CD38+CD23- centroblasts (Bm3) and IgD-CD38+CD77- centrocytes (Bm4) and memory IgD-CD38- (Bm5) subsets. Previous IgVH sequence analysis concluded that the triggering of somatic mutat...

Topics

B-Lymphocytes
Base Sequence
Cell Line
DNA
DNA Damage
Gene Rearrangement, B-Lymphocyte
Genes, Immunoglobulin
Germinal Center
Histocompatibility Antigens Class II
Humans
Immunoglobulin Class Switching
Molecular Sequence Data
Mutation
Palatine Tonsil
Sequence Deletion
Transcription, Genetic

Source

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Identifiers

PMID: 8624814
DOI: 10.1016/s1074-7613(00)80432-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8624814-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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