Article
Memory B lymphocytes in human tonsil do not express surface IgD.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1995
Nicholson I C, Brisco M J, Zola H
Abstract excerpt
To clarify the phenotype of memory B lymphocytes, we have determined the frequency of somatic hypermutations in purified tonsil B cell populations. Our particular interest was the controversial question of whether any memory B-cells express IgD. Ig heavy chain gene rearrangements that used the nonpolymorphic VH6 gene were amplified by PCR, cloned, and sequenced. All eight sequences obtained from the surface IgD...
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