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Article

Memory B lymphocytes in human tonsil do not express surface IgD.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1995

Nicholson I C, Brisco M J, Zola H

Abstract excerpt

To clarify the phenotype of memory B lymphocytes, we have determined the frequency of somatic hypermutations in purified tonsil B cell populations. Our particular interest was the controversial question of whether any memory B-cells express IgD. Ig heavy chain gene rearrangements that used the nonpolymorphic VH6 gene were amplified by PCR, cloned, and sequenced. All eight sequences obtained from the surface IgD...

Topics

Amino Acid Sequence
B-Lymphocyte Subsets
Base Sequence
Cloning, Molecular
DNA
Flow Cytometry
Gene Rearrangement, B-Lymphocyte
Humans
Immunoglobulin D
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunologic Memory

Molecular Sequence Data

Mutation

Palatine Tonsil

Polymerase Chain Reaction

Source

Identifiers

PMID: 7822787

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7822787-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Memory B lymphocytes in human tonsil do not express surface IgD.PMID 7822787Read ↗

Molecular analysis of IgD-positive human germinal centres.Semantic proximity Read ↗

Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells.Semantic proximity Read ↗

Analysis of somatic mutation in five B cell subsets of human tonsil.Semantic proximity Read ↗

Absence of surface IgD does not impair naive B cell homeostasis and memory B cell formation in humansSemantic proximity Read ↗

Human IgM+IgD+ B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life.Semantic proximity Read ↗

Memory B lymphocytes migrate to bone marrow in humans.Semantic proximity Read ↗

CD5+ B cells with the features of subepithelial B cells found in human tonsils.Semantic proximity Read ↗

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Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age.Semantic proximity Read ↗

Modulation of IgD and CD20 by ligation of CD5 on tonsillar B cells.Semantic proximity Read ↗

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