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Article

CD5+ B cells with the features of subepithelial B cells found in human tonsils.

European journal of immunology - 1 Aug 2007

Dono Mariella, Burgio Vito Lelio, Colombo Monica, Sciacchitano Salvatore, Reverberi Daniele, Tarantino Vincenzo, Cutrona Giovanna, Chiorazzi Nicholas, Ferrarini Manlio

Abstract excerpt

This study describes a CD5+ B cell that differs from the majority of the CD5+ B cells from human tonsils. This cell, isolated from in vivo activated B cells, expressed activation markers and featured a CD23-, IgMhigh, IgDlow surface phenotype, responded to T cell-independent type-2 antigens in vitro, and was detected in the subepithelial (SE) areas, the tonsil equivalent of the splenic marginal zone (MZ). Most of...

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Identifiers

PMID: 17615580
DOI: 10.1002/eji.200636887

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