Article
Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age.
The Journal of experimental medicine - 1 Oct 1994
Klein U, Küppers R, Rajewsky K
Abstract excerpt
Tonsillar germinal center and immunoglobulin M+ (IgM+)IgD+ B cells as well as peripheral blood (PB) CD5+ and CD5- (conventional) B cells from a 4-yr-old child were isolated and nucleotide sequences of expressed Ig heavy chain variable regions encoded by VH4 gene family members were determined fro...
Topics
- Amino Acid Sequence
- B-Lymphocyte Subsets
- Base Sequence
- Child, Preschool
- Cloning, Molecular
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Isotypes
- Immunoglobulin Joining Region
- Immunoglobulin Variable Region
- Immunologic Memory
- Molecular Sequence Data
- Mutation