Patterns of p53 mutations in squamous cell carcinoma of the lung. Acquisition at a relatively early age.

Article

Patterns of p53 mutations in squamous cell carcinoma of the lung. Acquisition at a relatively early age.

The American journal of pathology - 1 Dec 1994

Zheng J, Shu Q, Li Z H, Tsao J I, Weiss L M, Shibata D

Abstract excerpt

Squamous cell carcinoma (SQCC) of the lung is thought to arise after the accumulation of multiple mutations, including p53. To better characterize when p53 mutations are acquired, 37 SQCC of the lung were examined by polymerase chain reaction and single-strand conformation polymorphism analysis....

Topics

Aged
Aging
Carcinoma in Situ
Carcinoma, Squamous Cell
Female
Humans
Lung Neoplasms
Male
Middle Aged
Mutation
Tissue Distribution
Tumor Suppressor Protein p53

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