Article
Comparison of p53 mutations between adenocarcinoma and squamous cell carcinoma of the lung: unique spectra involving G to A transitions and G to T transversions in both histologic types.
Lung cancer (Amsterdam, Netherlands) - 1 May 2003
Gao Wei-Min, Mady Hussam H, Yu Guo-Ying, Siegfried Jill M, Luketich James D, Melhem Mona F, Keohavong Phouthone
Abstract excerpt
The p53 gene is frequently mutated in lung tumors, and mutations may be caused by both polycyclic aromatic hydrocarbons (PAHs) and nitrosamines found in tobacco smoke. The two major forms of lung cancer, adenocarcinoma (AC) and squamous cell carcinoma (SCC), are known to differ in the proportion of tumors exhibiting p53 mutation, and may also differ in the mutational spectra produced. Previous studies comparing...
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