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Article

Comparative power of family-based association strategies to detect disease-causing variants under two-locus models.

Genetic epidemiology - 1 Dec 2012

Babron Marie-Claude, Guilloud-Bataille Michel, Sahbatou Mourad, Demenais Florence, Génin Emmanuelle, Dizier Marie-Hélène

Abstract excerpt

Not accounting for interaction in association analyses may reduce the power to detect the variants involved. We investigate the powers of different designs to detect under two-locus models the effect of disease-causing variants among several hundreds of markers using family-based association tests by simulation. This setting reflects realistic situations of exploration of linkage regions or of biological...

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PMID: 22887021
DOI: 10.1002/gepi.21672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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