Article
Comparative power of family-based association strategies to detect disease-causing variants under two-locus models.
Genetic epidemiology - 1 Dec 2012
Babron Marie-Claude, Guilloud-Bataille Michel, Sahbatou Mourad, Demenais Florence, Génin Emmanuelle, Dizier Marie-Hélène
Abstract excerpt
Not accounting for interaction in association analyses may reduce the power to detect the variants involved. We investigate the powers of different designs to detect under two-locus models the effect of disease-causing variants among several hundreds of markers using family-based association tests by simulation. This setting reflects realistic situations of exploration of linkage regions or of biological...
Topics
- Family
- Genetic Association Studies
- Genetic Linkage
- Genetic Loci
- Genetic Predisposition to Disease
- Humans
- Models, Genetic
- Polymorphism, Single Nucleotide
- Research Design