Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of human CD4+, HIV-SF2 Nef-specific T-cell clones for antigen-processing and presentation requirements and for cytotoxic activity.

Vaccine - 1 Aug 1994

Wentworth P A, Steimer K S

Abstract excerpt

We have described previously the generation of seven HIV-SF2 Nef-specific, CD4+ T-cell clones, identification of epitopes within which are recognized by these clones, and the MHC alleles that restrict their responses. In this study, we have extended this characterization to include evaluation of antigen-processing and presentation requirements and cytotoxic activity. Clones were generated from five HIV-1...

Topics

Alleles
Amino Acid Sequence
Antigen Presentation
CD4-Positive T-Lymphocytes
Cells, Cultured
Clone Cells
Cytotoxicity, Immunologic
Gene Products, nef
Genes, MHC Class II
HIV-1
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocyte Activation

Molecular Sequence Data

Recombinant Proteins

T-Lymphocytes, Cytotoxic

nef Gene Products, Human Immunodeficiency Virus

Source

Identifiers

PMID: 7975829
DOI: 10.1016/0264-410x(94)90030-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7975829-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of human CD4+, HIV-SF2 Nef-specific T-cell clones for antigen-processing and presentation requirements and for cytotoxic activity.PMID 7975829Read ↗

Autologous HIV-1 clade-B Nef peptides elicit increased frequency, breadth and function of CD8+ T-cells compared to consensus peptides.Semantic proximity Read ↗

Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy.Semantic proximity Read ↗

Nef interference with HIV-1–specific CTL antiviral activity is epitope specificSemantic proximity Read ↗

Altering effects of antigenic variations in HIV-1 on antiviral effectiveness of HIV-specific CTLs.Semantic proximity Read ↗

Antibodies and lentiviruses that specifically recognize a T cell epitope derived from HIV-1 Nef protein and presented by HLA-C.Semantic proximity Read ↗

Three epitopic peptides of the simian immunodeficiency virus Nef protein recognized by macaque cytolytic T lymphocytes.Semantic proximity Read ↗

Functional characterization of HIV-1 Nef mutants in the context of viral infection.Semantic proximity Read ↗

Characterization of an HIV-1 p24gag epitope recognized by a CD8+ cytotoxic T-cell clone.Semantic proximity Read ↗

The antiviral efficacy of HIV-specific CD8⁺ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate.Semantic proximity Read ↗

Functional analysis of HIV type 1 Nef reveals a role for PAK2 as a regulator of cell phenotype and function in the murine dendritic cell line, DC2.4.Semantic proximity Read ↗

Impaired cytotoxic T lymphocyte recognition due to genetic variations in the main immunogenic region of the human immunodeficiency virus 1 NEF protein.Semantic proximity Read ↗

Fine specificity of the B-cell epitopes recognized in HIV-1 NEF by human sera.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.