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Article

Functional analysis of HIV type 1 Nef reveals a role for PAK2 as a regulator of cell phenotype and function in the murine dendritic cell line, DC2.4.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2005

Mann Jelena, Patrick Claire N, Cragg Mark S, Honeychurch Jamie, Mann Derek A, Harris Mark

Abstract excerpt

The HIV-1 Nef protein plays a critical role in viral pathogenesis. Nef has been shown to modulate dendritic cell (DC) function, in particular perturbing their ability to present Ag. To further characterize the effects of Nef on DCs, we established a panel of transfectants of the murine DC line, DC2.4, stably expressing differing levels of either wild-type Nef, or a number of Nef mutants lacking key functional...

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Source

Identifiers

PMID: 16272310
DOI: 10.4049/jimmunol.175.10.6560

Genes

PAK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Functional analysis of HIV type 1 Nef reveals a role for PAK2 as a regulator of cell phenotype and function in the murine dendritic cell line, DC2.4.PMID 16272310Read ↗

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