Article
Autologous HIV-1 clade-B Nef peptides elicit increased frequency, breadth and function of CD8+ T-cells compared to consensus peptides.
PloS one - 1 Jan 2012
Doroudchi Mehrnoosh, Yegorov Oleg, Baumgartner Tom, Kernaleguen Anne-Elen, Breton Gaelle, Ndongala Michel L, Boulassel Mohamed-Rachid, Routy Jean-Pierre, Bernard Nicole F, Sékaly Rafick-Pierre, Yassine-Diab Bader
Abstract excerpt
OBJECTIVE: To determine the function and phenotype of CD8(+) T-cells targeting consensus and autologous sequences of entire HIV-1 Nef protein. METHODS: Multiparameter flow cytometry-based analysis was used to evaluate the responses of two treatment naïve HIV-infected individuals, during primary and the chronic phases of infection. RESULTS: A greater breadth and magnitude of CD8 IFN-γ responses to autologous...
Topics
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Flow Cytometry
- Granzymes
- HIV-1
- Histocompatibility Antigens Class I
- Humans
- Immune System
- Interferon-gamma
- Leukocytes, Mononuclear