Article
Characterization of an HIV-1 p24gag epitope recognized by a CD8+ cytotoxic T-cell clone.
Immunology letters - 1 Mar 1997
Buseyne F, Stevanovic S, Rammensee H G, Rivière Y
Abstract excerpt
A CD8+ cytotoxic T-cell clone that recognized HIV p24gag was isolated from an infected individual. The minimal epitope was localized to amino acids 308-316 (QASQEVKNW). Using allogeneic target cells, we found that lysis was restricted by the HLA-Cw0401 molecule. We observed that C1R cells, that express the HLA-Cw0401 allele are able to present the peptide to the cytotoxic clone, but with reduced efficiency. Other...
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