Article
Fine specificity of the B-cell epitopes recognized in HIV-1 NEF by human sera.
Virology - 1 Mar 1992
Tähtinen M, Gombert F, Hyytinen E R, Jung G, Ranki A, Krohn K J
Abstract excerpt
We have previously used partially overlapping synthetic nonapeptides to characterize the human natural antibody response against HIV-1 negative regulatory factor (NEF), and identified nine 5 to 13 amino acid long regions that were recognized by sera of HIV-1-infected individuals. In this report we define the minimal size of these epitopes with the use of shorter, from 3 to 8 amino acid long partially overlapping...
Topics
- Amino Acid Sequence
- B-Lymphocytes
- Enzyme-Linked Immunosorbent Assay
- Epitopes
- Gene Products, nef
- Genetic Variation
- HIV Infections
- HIV-1
- Humans
- Molecular Sequence Data
- Peptide Fragments