Article
Heterogeneous expression and polymorphic genotype of glutathione S-transferases in human lung.
Thorax - 1 Oct 1994
Cantlay A M, Smith C A, Wallace W A, Yap P L, Lamb D, Harrison D J
Abstract excerpt
BACKGROUND: Glutathione S-transferases (GSTs) are involved in the detoxification of xenobiotics by conjugation with glutathione. One of the mu class genes of this superfamily of enzymes, GSTM1, is polymorphic because of a partial gene deletion. This results in a failure to express GSTM1 in approx...
Topics
- Base Sequence
- Blotting, Western
- Bronchoalveolar Lavage Fluid
- DNA
- DNA Primers
- Gene Deletion
- Gene Expression Regulation, Enzymologic
- Genotype
- Glutathione Transferase
- Humans
- Immunohistochemistry
- Isoenzymes
- Lung
- Lung Neoplasms
- Molecular Sequence Data
- Paraffin Embedding
- Polymerase Chain Reaction