Article
Heterogeneous expression and polymorphic genotype of glutathione S-transferases in human lung.
Thorax - 1 Oct 1994
Cantlay A M, Smith C A, Wallace W A, Yap P L, Lamb D, Harrison D J
Abstract excerpt
BACKGROUND: Glutathione S-transferases (GSTs) are involved in the detoxification of xenobiotics by conjugation with glutathione. One of the mu class genes of this superfamily of enzymes, GSTM1, is polymorphic because of a partial gene deletion. This results in a failure to express GSTM1 in approximately 50% of individuals. Several studies have linked GSTM1 null status to an increased risk of lung carcinoma. This...
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