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Article

The human glutathione S-transferase supergene family, its polymorphism, and its effects on susceptibility to lung cancer.

Environmental health perspectives - 1 Nov 1992

Ketterer B, Harris J M, Talaska G, Meyer D J, Pemble S E, Taylor J B, Lang N P, Kadlubar F F

Abstract excerpt

Cytosolic glutathione S-transferases (GSTs) are a supergene family of dimeric enzymes capable of detoxifying a number of carcinogenic electrophiles. Of the numerous components of tobacco smoke, the polycyclic aromatic hydrocarbons appear to be the principal compounds that yield substrates for the...

Topics

Animals
Anticarcinogenic Agents
DNA
Disease Susceptibility
Genotype
Glutathione Transferase
Humans
Lung
Lung Neoplasms
Polymorphism, Genetic
Rats
Smoking

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 1486868
DOI: 10.1289/ehp.929887
PMCID: PMC1519626

Genes

GSTM1
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1486868-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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