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Article

The human glutathione S-transferase supergene family, its polymorphism, and its effects on susceptibility to lung cancer.

Environmental health perspectives - 1 Nov 1992

Ketterer B, Harris J M, Talaska G, Meyer D J, Pemble S E, Taylor J B, Lang N P, Kadlubar F F

Abstract excerpt

Cytosolic glutathione S-transferases (GSTs) are a supergene family of dimeric enzymes capable of detoxifying a number of carcinogenic electrophiles. Of the numerous components of tobacco smoke, the polycyclic aromatic hydrocarbons appear to be the principal compounds that yield substrates for these enzymes, GSTM1-1 being effective with those PAH derivatives so far studied; however, the gene locus for GSTM1 is...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 1486868
DOI: 10.1289/ehp.929887
PMCID: PMC1519626

Genes

GSTM1
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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