Article
Glutathione S-transferase copy number variation alters lung gene expression.
The European respiratory journal - 1 Jul 2011
Butler M W, Hackett N R, Salit J, Strulovici-Barel Y, Omberg L, Mezey J, Crystal R G
Abstract excerpt
The glutathione S-transferase (GST) enzymes catalyse the conjugation of xenobiotics to glutathione. Based on reports that inherited copy number variations (CNVs) modulate some GST gene expression levels, and that the small airway epithelium (SAE) and alveolar macrophages (AMs) are involved early in the pathogenesis of smoking-induced lung disease, we asked: do germline CNVs modulate GST expression levels in SAE...
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