Article
Glutathione S-transferase mu polymorphism and susceptibility to lung cancer in the Portuguese population.
Teratogenesis, carcinogenesis, and mutagenesis - 1 Jan 1996
Moreira A, Martins G, Monteiro M J, Alves M, Dias J, da Costa J D, Melo M J, Matias D, Costa A, Cristóvão M, Rueff J, Monteiro C
Abstract excerpt
Epidemiological studies have led to the suggestion that a genetic basis may exist in the individual variation in predisposition to cancer. Interindividual differences in human toxicological response to carcinogenic exposure have been attributed to heritable polymorphisms in metabolism, namely glutathione S-transferases (GSTs) coding for enzymes that are known to be detoxifiers of carcinogens. Within the human GST...
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