Article
Genetic monitoring of human polymorphic cancer susceptibility genes by polymerase chain reaction: application to glutathione transferase mu.
Environmental health perspectives - 1 Nov 1992
Bell D A, Thompson C L, Taylor J, Miller C R, Perera F, Hsieh L L, Lucier G W
Abstract excerpt
Several genes involved in the metabolism of carcinogens have been found to be polymorphic in human populations and are associated with increased risk of cancer at some sites. This study focuses on the polymorphic enzyme glutathione transferase mu (GT mu). Smokers with low lymphocyte GT mu activity are at an approximately 2-fold higher risk for lung cancer and an approximately 3-fold higher risk for stomach and...
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