Article
Glutathione S-transferase mu locus: use of genotyping and phenotyping assays to assess association with lung cancer susceptibility.
Carcinogenesis - 1 Sept 1991
Zhong S, Howie A F, Ketterer B, Taylor J, Hayes J D, Beckett G J, Wathen C G, Wolf C R, Spurr N K
Abstract excerpt
In mammals, the cytosolic glutathione S-transferases (GSTs; EC 2.5.1.18) are a supergene family comprised of four multigene families, named alpha, mu, pi and theta. In man, within the mu class gene family there is a gene (the GSTmu 1 locus) that is polymorphic and is only expressed in 50-55% of i...
Topics
- Blotting, Southern
- Blotting, Western
- Chromosome Mapping
- DNA
- DNA Probes
- Genetic Predisposition to Disease
- Genotype
- Glutathione Transferase
- Heterozygote
- Homozygote
- Humans
- Lung Neoplasms
- Multigene Family
- Phenotype
- Polymorphism, Restriction Fragment Length
- Radioimmunoassay