Certain HLA-DR5 and -DR6 major histocompatibility complex class II alleles are associated with a CD8 lymphocytic host response to human immunodeficiency virus type 1 characterized by low lymphocyte viral strain heterogeneity and slow disease progression.

doi:10.1073/pnas.91.24.11472

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Article

Certain HLA-DR5 and -DR6 major histocompatibility complex class II alleles are associated with a CD8 lymphocytic host response to human immunodeficiency virus type 1 characterized by low lymphocyte viral strain heterogeneity and slow disease progression.

Proceedings of the National Academy of Sciences of the United States of America - 22 Nov 1994

Itescu S, Rose S, Dwyer E, Winchester R

Abstract excerpt

Either of two structurally related major histocompatibility complex class II alleles, DRB1*1102, which encodes a DR5 specificity, or DRB1*1301, which encodes a DR6 specificity, was found in 67% of individuals responding to human immunodeficiency virus type 1 (HIV-1) infection with a syndrome char...

Topics

Alleles
Base Sequence
CD8-Positive T-Lymphocytes
Ethnicity
HIV Envelope Protein gp120
HIV Seropositivity
HIV-1
HLA-DR Antigens
HLA-DR5 Antigen
HLA-DR6 Antigen
HLA-DRB1 Chains
Humans
Lymphocytosis

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Identifiers

PMID: 7972086
DOI: 10.1073/pnas.91.24.11472
PMCID: PMC45253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7972086-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.