Article
New class I and II HLA alleles strongly associated with opposite patterns of progression to AIDS.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1999
Hendel H, Caillat-Zucman S, Lebuanec H, Carrington M, O'Brien S, Andrieu J M, Schächter F, Zagury D, Rappaport J, Winkler C, Nelson G W, Zagury J F
Abstract excerpt
The genetics of resistance to infection by HIV-1 cohort consists of 200 slow and 75 rapid progressors to AIDS corresponding to the extremes of HIV disease outcome of 20,000 Caucasians of European descent. A comprehensive analysis of HLA class I and class II genes in this highly informative cohort has identified HLA alleles associated with fast or slow progression, including several not described previously. A...
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