Use of type 1/type 2 chimeric polioviruses to study determinants of poliovirus type 1 neurovirulence in a mouse model.

doi:10.1016/0042-6822(91)90078-p

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Article

Use of type 1/type 2 chimeric polioviruses to study determinants of poliovirus type 1 neurovirulence in a mouse model.

Virology - 1 Feb 1991

Martin A, Benichou D, Couderc T, Hogle J M, Wychowski C, Van der Werf S, Girard M

Abstract excerpt

We previously described the characteristics of a type 1/type 2 (PV-1/PV-2) chimeric poliovirus, v510, which contains the six amino acids specific for PV-2 in the B-C loop of VP1. This virus was found to be mouse-adapted, as PV-2 and in contrast with PV-1. Determinants of host range were studied in detail and are reported here. PV-1/PV-2 chimeras containing partial PV-1----PV-2 substitutions in the B-C loop of VP1...

Topics

Amino Acid Sequence
Animals
Base Sequence
Capsid
Capsid Proteins
Chimera
Cloning, Molecular
Escherichia coli
Female
Genetic Variation
HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Medulla Oblongata

Mice

Models, Molecular

Molecular Sequence Data

Mutagenesis, Insertional

Oligonucleotide Probes

Source

Open in PubMed

Identifiers

PMID: 1846492
DOI: 10.1016/0042-6822(91)90078-p

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1846492-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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