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Article

Precise missense and silent point mutations are fixed in the genomes of poliovirus mutants from persistently infected cells.

Journal of virology - 1 May 1993

Borzakian S, Pelletier I, Calvez V, Colbere-Garapin F

Abstract excerpt

Poliovirus mutants selected in persistently infected human neuroblastoma cells have a modified cell tropism and can establish a secondary persistent infection in nonneural cells, such as HEp-2c cells. Nucleotide sequence analysis revealed that the genome of a persistent mutant, S11, differed from that of the parental lytic Sabin 1 poliovirus strain by 31 point mutations. Three mutations occurred in the noncoding...

Topics

Capsid
Capsid Proteins
Genome, Viral
Humans
Mutation
Organ Specificity
Point Mutation
Poliovirus
Regulatory Sequences, Nucleic Acid
Selection, Genetic
Sequence Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

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Identifiers

PMID: 8386281
DOI: 10.1128/JVI.67.5.2914-2917.1993
PMCID: PMC237618

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