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Article

Precise missense and silent point mutations are fixed in the genomes of poliovirus mutants from persistently infected cells.

Journal of virology - 1 May 1993

Borzakian S, Pelletier I, Calvez V, Colbere-Garapin F

Abstract excerpt

Poliovirus mutants selected in persistently infected human neuroblastoma cells have a modified cell tropism and can establish a secondary persistent infection in nonneural cells, such as HEp-2c cells. Nucleotide sequence analysis revealed that the genome of a persistent mutant, S11, differed from that of the parental lytic Sabin 1 poliovirus strain by 31 point mutations. Three mutations occurred in the noncoding...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 8386281
DOI: 10.1128/JVI.67.5.2914-2917.1993
PMCID: PMC237618

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Source receipt: pubmed, retrieved 7 Sept 2026.

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