Article
ras oncogene activation does not induce sensitivity to natural killer cell-mediated lysis in human melanoma.
The Journal of investigative dermatology - 1 Nov 1994
van Elsas A, van Deursen E, Wielders R, van den Berg-Bakker C A, Schrier P I
Abstract excerpt
An important phenomenon in tumor immunology that has come under recent attention is the impact of oncogene activation in tumor cells on the sensitivity to lysis by immune effector cells. Several studies suggested that transfer of an activated ras oncogene into cultured rodent fibroblasts induces susceptibility to natural killer cell (NK)-mediated lysis. Experiments using human tumor cells, however, have produced...
Topics
- Base Sequence
- Cell Adhesion Molecules
- Cell Membrane
- Gene Expression Regulation
- Genes, ras
- Histocompatibility Antigens Class I
- Humans
- Killer Cells, Natural
- Melanoma
- Molecular Sequence Data