Article
Multiple mechanisms of immune evasion can coexist in melanoma tumor cell lines derived from the same patient.
Cancer immunology, immunotherapy : CII - 1 Jan 2001
Real L M, Jimenez P, Kirkin A, Serrano A, García A, Cantón J, Zeuthen J, Garrido F, Ruiz-Cabello F
Abstract excerpt
Progressive tumor growth may be associated with suppression of the immune response. Many different mechanisms may contribute to immune evasion. We investigated some of these mechanisms in melanoma cells lines generated from two patients. These cell lines show a complex pattern of altered HLA expression; however, the resulting phenotype did not satisfactorily explain the simultaneous evasion of T and NK cell...
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