Article
Analysis of the tumor suppressor activity of the K-rev-1 gene in human tumor cell lines.
Cancer research - 15 Jan 1994
Sato K Y, Polakis P G, Haubruck H, Fasching C L, McCormick F, Stanbridge E J
Abstract excerpt
Overexpression of the human K-rev-1 gene in v-Ki-ras-transformed NIH 3T3 cells has been reported to result in the reversal of transformation and tumor suppression. To address whether human K-rev-1 is a tumor suppressor gene of human tumor cells, we have systematically transfected epitope-tagged w...
Topics
- Animals
- Blotting, Northern
- Cell Transformation, Neoplastic
- Female
- Gene Expression Regulation, Neoplastic
- Gene Products, rev
- Genes, rev
- Humans
- Mice
- Mice, Nude
- Oncogene Protein p21(ras)
- Phenotype
- RNA, Messenger
- RNA, Neoplasm
- Transfection
- Tumor Cells, Cultured