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Article

N-RAS mutations and susceptibility to lymphokine-activated killer (LAK) cells in human melanoma.

Melanoma research - 1 Feb 1994

Lupetti R, Sensi M, Mortarini R, Anichini A, Clemente C, Parmiani G

Abstract excerpt

RAS oncogene expression has been reported to affect several biological features of rodent tumours cells, including lysability by activated natural killer cells. In order to examine whether expression of mutated RAS genes in human melanoma cells alters their susceptibility to lysis by LAK cells, seven melanoma lines were assessed for the presence of Ki- and N-RAS genes bearing all possible mutations at codons 12,...

Topics

Base Sequence
Clone Cells
Gene Expression Regulation, Neoplastic
Genes, ras
Humans
Immunotherapy, Adoptive
Killer Cells, Lymphokine-Activated
Lymphocyte Activation
Melanoma
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transfection

Tumor Cells, Cultured

Source

Identifiers

PMID: 8032213
DOI: 10.1097/00008390-199402000-00003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8032213-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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