Article
The susceptibility to natural killer cell-mediated lysis of HLA class I-positive melanomas reflects the expression of insufficient amounts of different HLA class I alleles.
European journal of immunology - 1 Aug 1998
Pende D, Accame L, Pareti L, Mazzocchi A, Moretta A, Parmiani G, Moretta L
Abstract excerpt
NK cells selectively lyse tumor cells which do not express one or more MHC class I alleles. The ability to discriminate between self normal or tumor cells is due to the expression of MHC class I-specific killer inhibitory receptors (KIR). In the present study we analyzed melanoma cell lines which...
Topics
- Alleles
- Antibodies, Monoclonal
- Autoimmunity
- B-Lymphocytes
- Cell Line
- Cell Transformation, Viral
- Cytotoxicity, Immunologic
- Down-Regulation
- Gene Expression
- Genes, MHC Class I
- Herpesvirus 4, Human
- Humans
- Interferon-gamma
- Killer Cells, Natural