Evidence for indirect involvement of the H-2Kb gene in the regulation of natural killer sensitivity of BL6 melanoma cells.

Article

Evidence for indirect involvement of the H-2Kb gene in the regulation of natural killer sensitivity of BL6 melanoma cells.

Natural immunity - 1 Jan 2000

Kim M, Herberman R, Gorelik E

Abstract excerpt

We have previously demonstrated that transfection of BL6-8 melanoma cells with the H-2Kb gene increased their sensitivity to natural killer (NK)- and natural cytotoxic (NC) cell-mediated cytotoxicity, and resulted in alterations of various cell characteristics such as the loss of melanoma-associa...

Topics

DNA, Neoplasm
Gene Expression Regulation, Neoplastic
H-2 Antigens
Killer Cells, Natural
Melanoma, Experimental
Phenotype
Transfection
Tumor Cells, Cultured

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