Article
E1A gene expression induces susceptibility to killing by NK cells following immortalization but not adenovirus infection of human cells.
Virology - 10 Jul 1995
Routes J M, Cook J L
Abstract excerpt
Adenovirus (Ad) infection and E1A transfection were used to model changes in susceptibility to NK cell killing caused by transient vs stable E1A expression in human cells. Only stably transfected target cells exhibited cytolytic susceptibility, despite expression of equivalent levels of E1A prote...
Topics
- Adenovirus E1A Proteins
- Adenovirus Early Proteins
- Adenoviruses, Human
- Cell Line, Transformed
- Cytotoxicity, Immunologic
- Gene Expression
- Genes, Viral
- Histocompatibility Antigens Class I
- Humans
- Killer Cells, Natural
- Mutation
- Transfection
- Tumor Cells, Cultured