Article
Can oncogene (RAS) activation predict susceptibility of human melanoma to activated lymphocytes and, therefore, the clinical response of such neoplasms to adoptive immunotherapy?
Melanoma research - 1 Jul 1992
Parmiani G, Anichini A, Carbone G, Sensi M
Abstract excerpt
The expression of activated ras oncogenes was found to be associated with that of tumour-specific transplantation antigens in mouse tumours, which can be cured by adoptive immunotherapy with T lymphocytes and interleukin-2 (IL-2). A similar association is here proposed to exist between RAS oncogene activation (mutation) in human melanoma and susceptibility of these tumours to the lytic action of activated...
Topics
- Animals
- Genes, ras
- Humans
- Immunotherapy, Adoptive
- Lymphocyte Activation
- Melanoma
- Mutation