Article
Suppression of oncogenic NRAS by RNA interference induces apoptosis of human melanoma cells.
International journal of cancer - 20 May 2005
Eskandarpour Malihe, Kiaii Shahryar, Zhu Chaoyong, Castro Juan, Sakko Andrew J, Hansson Johan
Abstract excerpt
The majority of human melanomas harbor activating mutations in either the BRAF or NRAS gene. To date, the role of oncogenic NRAS in melanoma remains poorly defined and no current therapies are directed at specifically suppressing oncogenic NRAS in human melanoma tumors. The aim of our study, therefore, was to investigate the effects of suppressing oncogenic NRAS in human melanoma cell lines in vitro. Using both...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.