Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast.

doi:10.1016/0092-8674(93)90387-6

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Article

Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast.

Cell - 5 Nov 1993

Chien C T, Buck S, Sternglanz R, Shore D

Abstract excerpt

Previous studies suggest that the yeast SIR1 protein is involved in the establishment of transcriptional silencing at the HM mating-type loci. Here we show that a GAL4 DNA-binding domain-SIR1 hybrid protein (GBD-SIR1), when targeted to an HMR locus containing GAL4-binding sites (UASG), can establ...

Topics

Crosses, Genetic
DNA-Binding Proteins
Fungal Proteins
Gene Expression Regulation, Fungal
Genes, Fungal
Genes, Mating Type, Fungal
Histones
Mating Factor
Models, Genetic
Mutation
Peptides
Recombinant Fusion Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Silent Information Regulator Proteins, Saccharomyces cerevisiae

Telomere

Trans-Activators

Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 8221892
DOI: 10.1016/0092-8674(93)90387-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8221892-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast.PMID 8221892Read ↗

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The Ku complex in silencing the cryptic mating-type loci of Saccharomyces cerevisiae.Semantic proximity Read ↗

Spreading of transcriptional repressor SIR3 from telomeric heterochromatin.Semantic proximity Read ↗

A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR.Semantic proximity Read ↗

Elaboration, diversification and regulation of the Sir1 family of silencing proteins in Saccharomyces.Semantic proximity Read ↗

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Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants.Semantic proximity Read ↗

Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.Semantic proximity Read ↗

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Identification of a novel allele of SIR3 defective in the maintenance, but not the establishment, of silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

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