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Article

Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast.

Cell - 5 Nov 1993

Chien C T, Buck S, Sternglanz R, Shore D

Abstract excerpt

Previous studies suggest that the yeast SIR1 protein is involved in the establishment of transcriptional silencing at the HM mating-type loci. Here we show that a GAL4 DNA-binding domain-SIR1 hybrid protein (GBD-SIR1), when targeted to an HMR locus containing GAL4-binding sites (UASG), can establish silencing and bypass the requirement for the silencer element HMR-E. Silencing mediated by GBD-SIR1 requires the...

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PMID: 8221892
DOI: 10.1016/0092-8674(93)90387-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast.PMID 8221892Read ↗

Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1.Semantic proximity Read ↗

The Ku complex in silencing the cryptic mating-type loci of Saccharomyces cerevisiae.Semantic proximity Read ↗

Spreading of transcriptional repressor SIR3 from telomeric heterochromatin.Semantic proximity Read ↗

A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR.Semantic proximity Read ↗

Elaboration, diversification and regulation of the Sir1 family of silencing proteins in Saccharomyces.Semantic proximity Read ↗

The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging.Semantic proximity Read ↗

Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants.Semantic proximity Read ↗

Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.Semantic proximity Read ↗

Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length.Semantic proximity Read ↗

Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p.Semantic proximity Read ↗

Identification of a novel allele of SIR3 defective in the maintenance, but not the establishment, of silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

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